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Exploratory efficacy criteria included scales for which no significant benefit was expected, but which were worth examining in preparation for the next clinical trial: on actimetry, the bradykinesia score (50th percentile: normal value = 18.6)

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Identifying senescent cells in scRNA-seq data is challenging because the markers traditionally used to identify senescent cells are lowly expressed, expressed in select cell types in single-cell data and/or assayed in terms of cellular localization and enzymatic function 35

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