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While these findings underscore the central role of autoreactive T cells, emerging evidence suggests that intrinsic beta-cell factors, including oxidative stress and post-translational modifications (PTM), may also contribute to their immunogenicity, shedding new light on the multifaceted pathogenesis of T1D ( Building upon the understanding of genetic and immune factors in T1D, the detection of autoantibodies against key beta-cell antigenssuch as insulin, glutamate decarboxylase (65) (GAD65), zinc transporter 8 (ZnT8), and insulinoma antigen-2 (IA-2)provides a powerful diagnostic tool ( Hence, the questions arise: why has the immune system specifically turned on the beta-cells

10.1007/s00405-021-06628-5 39 LeeH

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Resveratrol prevents the development of hypertension programmed by maternal plus post-weaning high-fructose consumption through modulation of oxidative stress, nutrient-sensing signals, and gut microbiota

Nebulized medications are one of the options we can provide to our patients

Researchers have examined applications involving chronic wounds, delayed recovery, and situations characterized by slower wound healing