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In the acute phase, the neuroinflammatory response worsens BBB injury by degrading tight junctions and the extracellular matrix, promoting neuroglial proliferation, and activating cardiomyocytes, thereby further increasing its permeability

HGF largely originate from mesenchymal cells which acts in a paracrine manner on epithelial cells that express the c-MET receptor

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None of the hypotheses proposed so far explains the pathogenesis of vitiligo entirely

RodinoKlapac LR, Haidet AM, Kota J, Handy C, Kaspar BK, Mendell JR