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Unlike some peptides that require cycling to prevent receptor desensitization, AOD-9604 does not appear to lose efficacy with continuous use based on available data

10.1038/s41598-017-13974-0 456 VoglT.KalkaI

Chang, A., Jeske, L., Ulbrich, S., Hofmann, J., Koblitz, J., Schomburg, I., Neumann-Schaal, M., Jahn, D., Schomburg, D

Deslee G, Woods JC, Moore C, et al

Pharmacol Res 194:106841

Therefore, CHOP regulates mitochondrial dysfunction and mitochondria-related intrinsic apoptosis via Bcl2, Bim, and caspases
