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However, synthetic hydrogels may lack biocompatibility and can be toxic when certain polymers react, significantly limiting their use in medical treatments (Hu et al., 2025)

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G., Whittaker, R

[DOI] [PubMed] [Google Scholar] 287.Hasegawa T, Iino S, Kitakaze K, Kato T, Kabata D, Oyama N

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Silencing P65 or EAAT3 increases ROS levels and reduces GSH synthesis, but these changes alone are insufficient to trigger significant cell death due to the robust ferroptosis-resistance mechanisms in cancer cells, including the xCT-GSH-GPX4 system and other protective pathways