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This persistent elevation indicates that PBM may help preserve the primary enzymatic defense system against OS, potentially enhancing resilience to RT-induced damage, even if it does not directly reduce ROS levels

Functionally, each pathway circumvents melanomas intrinsic apoptosis resistance, and their dysregulationvia genetic mutations, epigenetic silencing, or metabolic reprogrammingcontributes to tumor progression and therapeutic resistance, highlighting their shared role as tumor-suppressive mechanisms when functionally intact (112, 114)

Combined with Figs

Eng, 2018, 6, 1075110757

The molecular defences against reactive oxygen species in yeast

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