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The speed of response depends on factors including the severity and duration of deficiency, the presence of neurological complications, and individual metabolic differences

Instead, the CobaSorb test that measures change in serum holoTC concentrations following an oral dose of unlabeled B12 can be used

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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

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