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The maladaptive neural plasticity believed to underlie chronic tinnitus could be influenced by epigenetic mechanisms

For researchers standardising input across in vivo rodent model cohorts, capsules present several practical considerations when compared with the MK-677 liquid format: Unit consistency: Fixed-content capsules reduce variability between experimental units, which may support cleaner comparisons across subjects in a study group

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Accordingly, a pragmatic translational pipeline uses 2D monocultures for feasibility screening, co- and tricultures for intercellular validation, 3D systems for human-relevant architecture and quantitative endpoints, and ex vivo and in vivo models for lesion- and organism-level confirmation

10.1007/s00204-019-02538-y 10.1007/s00204-019-02538-y [DOI] [PubMed] [Google Scholar] Singh N, NaveenKumar SK, Geethika M, Mugesh G (2021) A cerium vanadate nanozyme with specific superoxide dismutase activity regulates mitochondrial function and ATP synthesis in neuronal cells