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Interestingly, 9 desaturase activity is diet-regulated, with diets rich in unsaturated fatty acids repressing its expression (Brock et al, 2007
Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials
Nitric oxide activates the cGMP pathway
2008;294:C451C459
Dermatologists also call this lesion a labial lentigo or lip melanosis
The requirement for NS3 may have to do with correct folding, as NS2/3 cleavage is enhanced by Zn 2+ , which has a structural role in stabilizing the NS3 fold
