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Graphical Abstract Keywords Acetaminophen, Caspase-1, Drug-induced liver injury, Inflammasome, NOD-, LRR-, and pyrin domain-containing 3, NLRP3 Introduction Acetaminophen (APAP), commonly known as paracetamol, is a widely used over-the-counter medication renowned for its analgesic and antipyretic properties

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depending on the presence of this effector, it can adopt either a lowaffinity dimeric state or a highaffinity tetrameric state for phosphoenolpyruvate 146,151

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