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Ling B, Authier N, Balayssac D, Eschalier A, Coudore F

Chemosphere 55 , 533538 (2004)

Cofactor for L-methylmalonyl-coenzyme A mutase 5-Deoxyadenosylcobalamin is required by the enzyme that catalyzes the conversion of L-methylmalonyl-coenzyme A to succinyl-coenzyme A (succinyl-CoA), which then enters the citric acid cycle ( Figure 2 )

In contrast, excessive formation of ROS is responsible for disrupted redox homeostasis which in turn leads to oxidative stress and ROS-mediated damage to all important biomolecules including DNA, proteins, and membranes (Liguori et al

utilized differential centrifugation to substantiate that cirrmtDNA exists in multiple physical states

Sokolova O, Naumann M