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In the SURMOUNT-1 clinical trial, participants on the highest dose achieved 22.5% body weight reduction over 72 weeks

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Serious side effects of the medication include the following: Allergic or hypersensitivity reaction Severe gastrointestinal issues Changes in mood and behavior Pancreatitis Liver problems Low blood sugar levels (hypoglycemia) Cardiac arrhythmias Suicidal ideation Major depressive disorder No adverse event of hypoglycemia or thyroid cancer was reported in Phase II trials, and 7% of retatrutide participants had skin sensitivity, compared to 1% on placebo, but these cases were not serious

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1-2 vials per day, only via deep intramuscular injection