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2016 May;18(3):373
Those with cardiovascular issues should also use caution because of potential effects on heart rate and blood pressure
doi: 10.1038/nature11327 64 HicksDRafieeGSchwalbeECHowellCILindseyJCHillRMet al

These usually resolve without them needing any treatment

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Reconstructing sickle cell disease: a data-based analysis of the hyperhemolysis paradigm for pulmonary hypertension from the perspective of evidence-based medicine