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More recent systematic reviews and meta-analyses published between 2020 and 2022 have broadly confirmed this picture, reporting small, short-term reductions in body weight and body mass index, particularly in older adults and individuals with obesity or metabolic conditions, but with effect sizes that remain clinically modest

An LTQ Orbitrap MS interfaced to an Agilent 1200 LC was used for LCMS/MS analysis

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The etomoxir intervention group had 18 administrations of Etomoxir over a span of 28 days, receiving etomoxir without rotenone intervention from day 50 until 56 and again from day 58 until 60