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In the context of nanomaterials, factors such as particle size, dosage regimen, administration route, surface chemistry, degree of aggregation, transmembrane diffusivity, excretion mechanisms, and immunogenic potential are the key determinants of nanotoxicity

Approximately 0.5 g (coin size) of lotion was spread evenly on the designated test site twice daily (7:30 am to 9:00 am, 4:00 pm to 5:30 pm) for 10 consecutive weeks

10.1089/ten.2006.12.2253 180 MohammadpourH.PourfathollahA