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Indeed, the effects of oral water load on hyaluronidase activity have at present been studied essentially in vitro ( Although the inverse relationship between the renal excretion of hyaluronidase and body hydration has been known since 1958 ( In our study, the changes in hyaluronidase activity were accompanied by broadly comparable variations over time in serum copeptin levels and urinary AQP2/creatinine ratio, which we have previously shown to reliably reflect body water balance and vasopressinergic system activation ( Significantly, prior to oral water load and 4 hours after, that is under physiological conditions in the context of a sodium- and potassium-controlled diet, urinary hyaluronidase activity was positively correlated with SBP levels, which, in turn, were positively associated with the urinary AQP2/creatinine ratio at 0 and 40 min, corresponding to BP rise in response to the oral water load

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