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The activated Nrf2-sMaf heterodimer binds to antioxidant response element (ARE) sequences in the promoter of a tandem of antioxidant genes, including heme oxygenase-1 (HMOX1), aldo-keto reductases, glutathione, and glutathione-S-transferase (Tonelli et al., 2018), to trigger their expression

This disrupts the interaction between LDHB and LONP1, leading to the accelerated degradation of TFAM ( Figure 3 )

found that circLMO7 activated the WNT2/-catenin signaling pathway by releasing miR-30a-3p, which inhibits its target gene WNT2 (64)

Novo Nordisk, a pharmaceutical company based in Denmark, made the first of the recent blockbuster drugs, Ozempic, which emerged on the scene as a drug for people with diabetes

Knockout studies of DNA methyltransferases ( DNMT1 or DNMT3A/DNMT3L ) result in impaired spermatogenesis and infertility, underscoring the importance of methylation in gametogenesis and embryonic development [177, 178]

Studies in rat liver canalicular membrane vesicles provided the first direct evidence for GSH transport on Mrp2 (Rebbeor et al., 2002)