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At the same time, direct evidence shows that fibroblast migration is modulated through extracellular vesicles derived from macrophages [153], as the vesicles carry a rich cargo of growth factors, cytokines, and microRNAs that can alter the inflammatory milieu, promote angiogenesis, and directly or indirectly stimulate fibroblast proliferation and activation [151,153,154]

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Early multiorgan failure, thrombosis, intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, and aortal hypotension, in its full presentation (i.e., giant T-wave) or attenuated by BPC 157 therapy (i.e., normal T-wave) may be decisive for further isoprenaline-lesion development, similar to that noted with major intoxication (i.e., alcohol, lithium) or major vessel occlusion [14,15,16,17,18,19,20,21,22,23]
