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New and non- thermal technologies such as High Pressure Processing, Micro-filtration and Moderate Electric filed has been used as a pasteurization alternative which can prevent the destruction of bioactive compounds occurring due to heat treatment

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In a study published in 2017, the long-term use of metformin (Glucophage), an anti-diabetic medication, was correlated with a lower risk of gallstones in diabetic subjects (Liao 2017)

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