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When free radicals build up in the mitochondria, energy production slows down

Intriguingly, breast cancer cells metastasized to the brain are less sensitive to glucose deficiency (136), which may attribute to upregulation of glutamine and branched chain amino acid oxidation (143)

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Secondly, the role of antidepressants in reducing oxidative stress should not be overlooked [70], as it may help maintain the lipid balance of neural cells, particularly the stability of membrane sphingolipids, which are essential for neuronal function and survival [71]