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4850 The brain is especially sensitive to defective ATP7A protein and copper deficiency since the passage of copper across the bloodbrain barrier (BBB) is mediated by ATP7A, and several cuproenzymes (e.g
10.1016/j.cell.2011.02.013 48 HazlittR

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Annu Rev Med 53:409435 Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE (2014) Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases

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