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doi: 10.3389/fcvm.2024.1345218 Received 27 November 2023 Accepted 15 January 2024 Published 02 February 2024 Volume 11 - 2024 Edited by Tlili Barhoumi, King Abdullah International Medical Research Center (KAIMRC), Saudi Arabia Reviewed by Gianfranco Pintus, University of Sharjah, United Arab Emirates Rosa Vona, National Institute of Health (ISS), Italy Valeria Visco, University of Salerno, Italy Updates Copyright 2024 Caminiti, Carresi, Mollace, Macr, Scarano, Oppedisano, Maiuolo, Serra, Ruga, Nucera, Tavernese, Gliozzi, Musolino, Palma, Muscoli, Rubattu, Volterrani, Federici, Volpe and Mollace

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doi: 10.1373/clinchem.2006.073882

2.4 Bioreductive reactive small molecule prodrugs Approximately 50% of cancer patients with solid tumors will receive platinum (Pt)-based anticancer drugs during chemotherapy (Miller et al., 2020)

However, during the treatment of neonatal hyperbilirubinemia, the level of free bilirubin in the serum is decreased, which may weaken the protective effect of bilirubin on the cell membrane, thus making the cell membrane susceptible to injury and causing cell apoptosis