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Worldwide polymorphism at the MC1R locus and normal pigmentation variation in humans

101 MencarelliA.RengaB.DistruttiE.FiorucciS

Experts have not found evidence of alcohol impairing the effectiveness of the medicine

Freckles and moles have two things in common: there is a genetic tendency to get them, and both are darker than the surrounding skin

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This chromatic variability not only reflects the genetic factors that regulate melanin synthesis by melanocytes and its subsequent transfer to adjacent keratinocytes but is also influenced by external factors such as trauma, inflammation, hormonal fluctuations, exposure to certain pharmacological agents, external agents that can pigment the mucosa, and radiation, all of which can induce an increase in melanin production