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However, due to the strong occult nature of the disease and atypical clinical symptoms, a large number of HT have not been diagnosed

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These systems can switch their surface charge in response to tumour microenvironment (TME) triggers such as pH changes, redox states, or enzymatic activity, enhancing drug stability, facilitating cellular uptake, and enabling targeted drug release

Dizdaroglu, M., Coskun, E

The control of nuclear thioldisulfide redox states by nucleoredoxins and TRX1 remains, however, largely uncharacterized (Kneeshaw et al

Similarly, coronary artery disease patients with single, double, or triple-vessel stenosis and patients with acute coronary syndrome had a significant increase in malondialdehyde levels and the percentage of malondialdehyde release, associated with a marked decrease in GSH concentration, total antioxidant capacity and erythrocyte GSH peroxidase activity compared with controls (154)