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Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM
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NIK serves as a key signaling mediator of a subset of TNF receptor (TNFR) superfamily members and is involved in diverse functions of the immune system, including lymphoid organ development, B cell survival and maturation, and T cell effector function
