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Theabrownin has been shown to reverse insulin resistance in HepG2 cells through the IRS/PI3K/Akt signaling pathway, to regulate GSK3, G6Pase, glucokinase, PEPCK1 and other related indicators, reduce oxidative stress (83)

doi: 10.1038/s41586-020-2222-z 108 NajmAMassonFMPreussPGeorgesSOryBQuillardTet al

Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules

Release 337 , 168178 (2021)

Given the pivotal role of mitochondria in energy production, their damage can significantly reduce sperm motility and vitality, diminishing reproductive potential [27]

Possible Side Effects and Safety Considerations Both berberine and L-carnitine are generally considered safe when used appropriately, but each carries potential adverse effects that users should be aware of, particularly when considering concurrent use