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The first step in methionine catabolism is the generation of S-adenosylmethionine (SAMe), the principal biological methyl donor, in a reaction catalyzed by methionine adenosyltransferase (MAT) [55]

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1 Introduction Radiation therapy is a cornerstone treatment in modern oncology

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However, the moral imperative to avoid/minimise harm (arising from the principle of non-maleficence) also requires the mitigation of the possible harm of causing distress to families if these conversations were to be handled poorly