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36 Mechanistic studies have shown that increased glucose levels can stimulate reactive oxygen species (ROS) production through protein kinase C (PKC)-dependent stimulation of NAD(P)H oxidase
Two of them are critical for the cysteinyl t-RNA synthesis and subsequent protein translation, and the other two are critical for the persulfide synthesis
The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]
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When you have more melanin in your skin, it appears darker
