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doi: 10.2337/db11-1024 108

Perhaps most amazingly, the mices behavior changed, too frail mice seemed to grow younger and began to explore, exercise, and respond to physical stimuli just like healthy young mice did

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Irrespective of its mechanism of action, cuprizone is a widely utilised and validated toxin for modelling CNS demyelination that is not directly associated with peripheral autoimmunity 20

Here, we review the homeostatic and immunoregulatory functions of HO-1, whose induction differentially affect the course of various pathologies