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The research indicates upregulation of p53-pS15 and p16 maintains a persistent senescent microenvironment that promotes cell cycle arrest and apoptosis resistance in keloid fibroblasts, perpetuating pathological scar formation

22,51,59,261,262 Similarly, protein fusions including fluorescent proteins, 187,263,264 high affinity luciferase complementation reporters, 95,265 tetracysteine tags, 266268 and purification or antibody epitope tags for Western blotting 95,135,141,269,270 have been used to quantify the products of translation

Ziegenhain C, Vieth B, Parekh S, et al

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JackCAndrewsJBeachTBuracchioTDunnBGrafAet alRevised criteria for diagnosis and staging of Alzheimers disease: Alzheimers association workgroup

Its just a theory, and its been used as a theory, but its turned into dogma