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These two microarray datasets were detected by the same platform (HG-U133A) Affymetrix Human Genome U133A Array

In treating solid tumors, developing more tumor-targeting ASNase is one aspect, and the SLC1A3 inhibitor mentioned earlier also provides an idea to solve this problem

During AD, an uncoupling between the insulin receptor (IR) and the insulin receptor substrate 1 (IRS1) occurs as a consequence of the downregulation of IR expression and/or the inactivation of IRS proteins leading to the inability of insulin to promote its normal cellular downstream outcomes

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Nat Med (2006) 12(3):31723

[PubMed] [Google Scholar] 11.Levine M., Dhariwal K.R., Welch R.W., Wang Y., Park J.B