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Several promising compounds have failed in clinical trials due to a range of challenges, including inadequate disease models, late intervention timing, insufficient biomarker validation, and difficulty in distinguishing symptomatic from neuroprotective effects

[DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted] 81.Pan S.J., Ren J., Jiang H., Liu W., Hu L.Y., Pan Y.X., Sun B., Sun Q.F., Bian L.G

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