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You can have the most brilliantly designed study in the world, but if your source material is impure, the results will be meaningless

doi: 10.1016/s0163-7258(00)00105-4

However, the FDA has interpreted this study and put a warning on febuxostat that it should be used second line, after allopurinol

pmid:33032595CrossRefPubMedGoogle Scholar Caballero MR, Lukawska J, Lee TH, Dugu P

Nature Medicine, 30(6), 1639-1647

Over time, the central nervous system itself becomes sensitized
