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Inhibition of ferroptosis to alleviate renal fibrosis: Studies indicate that targeting ferroptosis specifically with certain inhibitors can mitigate kidney damage and renal fibrosis: (1) In a 5/6 nephrectomy-induced CKD rat model, deferoxamine alleviates kidney injury and fibrosis by regulating iron metabolism and the TGF-1/Smad3 pathway (199)

437,438 Elevated serum levels of soluble intracellular adhesion molecule 1 (sICAM-1), indicative of increased vascular inflammation and/or endothelial dysfunction, have also been reported in PDPN

doi: 10.3390/ijms26136271 302 YangT.LiS.XuH.WalshD

GFR, glomerular filtration rate

In the current research, we used a cumulative dose of DOX injections to induce an experimental nephrotic syndrome model

26 , 16411650 (2009) Acknowledgements We thank J