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Mar 1 2002;7:d752-64

Blood levels drop from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60

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IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration

When levels drop, replenishing B12 directly can help support both physical and mental well-being

Adipose tissues release numerous metabolic hormones, cytokines, and other mediators, such as glycerol, leptin, adiponectin, and nonesterified fatty acids (NEFAs) [6]
