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Furthermore, inhibitors of system Xc as cystine transporters, such as erastin, sulfasalazine, and sorafenib, trigger ferroptosis [39]

This suggests that breast cancer patients with ASS1 deficiency might be candidates for arginine starvation therapy

This behavior seems to be descriptive of the cDDP-sensitive cells presently studied, whereas the R cells exhibit all opposite features: decreased ERK activity, decreased lactate formation and NAD + levels (compared to S cells)

The findings shed light on the different strategies these two cell types employ to evade drug toxicity