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EPA and DHA also activate the gene encoding the G-protein coupled receptor 120 (GPR120) which is expressed in inflammatory macrophages and in vivo when obese mice are supplemented with these PUFAs (isocaloric high fat diet containing 27% fish oil supplementation enriched with 50 and 100 mg of DHA and EPA, respectively, per mouse, per Day) [70]

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Likewise, corneal neovascularization might be induced by hypoxic conditions (upregulation of proangiogenic factors, downregulation of anti-anxiogenic factors to supply oxygen to the cornea) [181]

Emerging evidence reveals that UVR can induce both local and systemic responses, including modulation of immune function and regulation of neuroendocrine pathways, independent of its role in vitamin D production