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Description
Adenosine is a signaling molecule that regulates inflammation, immune responses, and vascular tone

Binding and entry leads to a cascade of steps resulting in inflammation and ultimately systemic disease [2]

N., Skaaby, T., Jrgensen, T., Thuesen, B

Similarly, disrupted neurogenesis is also observed in iPSC-models of fAD containing mutations in PSEN1 and further corroborated in hippocampal models, all noting a decrease in Notch signaling
After feeding mice a vitamin E-adequate and a vitamin E-deficient diet, the researchers found that the vitamin E-deficient mice showed a 90-fold decrease of -tocopherol in lung tissue, and a significant decrease of antioxidants and increased inflammatory response (182)

10.3390/molecules28062636 38 EntezariS.HaghiS
