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Due to their homology with bacterial subtilisin and yeast kexin proteases, PCs are also known as the PC subtilisin/kexin type (PCSK) enzymes 330

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PGD 2 production in DMD is involved in the expansion of muscular necrosis caused by muscular inflammation based on the observation that the administration of HPGDS inhibitors, including HQL79, TAS204, and TAS205, ameliorates muscular atrophy by decreasing urinary tetranor-PGDM concentrations in animal models 10,19,20,21 and in patients with DMD 22,23