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Additionally, preclinical animal studies have indicated that kratom extract mitigates withdrawal symptoms in morphine-dependent rats and produces analgesic effects comparable to conventional opioids, highlighting the role of serotonergic pathways in kratoms mechanism of action [44, 45]

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The elderly who have diets with limited animal-sourced foods are vulnerable populations for that reason and also because intestinal absorption declines with age, a consequence of low stomach acid