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Hepatic IGF-1 synthesis then ramps up, with circulating IGF-1 elevations measurable 12 to 24 hours after a single dose and steady state reached after roughly 14 days of daily dosing

Int J Mol Sci 24:728

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[DOI] [PubMed] [Google Scholar] 74.Fang L., Karakiulakis G., Roth M

B12 deficiency symptoms usually begin gradually, but can become more serious over time

These variables determine how quickly blood alcohol concentration rises and how long impairment lasts