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Second, an in vitro chromosome aberration assay was performed in Chinese Hamster Ovary (CHO) cells treated with AOD9604 (20, 50, 100, 200 g/mL) in the absence or presence of an S-9 metabolic activation system

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To address this gap, we propose the concept of a Dynamic Living Digital Twin framework for precision dosing in critical illness

Up to 1520% of adults have low or borderline B12 levels , and deficiency is a known cause of neuropathy

Hemoglobin concentrations (mmol/L) of ARA 290 patients compared with placebo were 8.9 0.21 (standard error of the mean [SEM]) versus 8.6 0.26 at baseline and 8.7 0.19 versus 8.7 0.34 at the end of dosing on wk 4