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Molecular mechanisms and physiological importance of circadian rhythms

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The miR-134-5p inhibitor proposed by the investigators for the treatment of bronchopulmonary dysplasia (BPD) achieves a certain therapeutic effect, but it still suffers from the problems of conventional drugs such as drop targeting and low solubility

Additionally, Kong et al [41] showed that dietary factors metabolised by gut microbes can produce trimethylamine, which is transported to the liver and converted by hepatic flavin mono-oxygenase 3 (FMO3) into trimethylamine N -oxide (TMAO)

Reduced the dosage by no more than 0.5 mg every 3 days
