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The ferredoxin/thioredoxin system of oxygenic photosynthesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Xu C., Sun S., Johnson T., Qi R., Zhang S., Zhang J., Yang K

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These studies demonstrated that GCN2-deficient T cells are resistant to IDO-mediated proliferation arrest and TCR -chain downregulation, suggesting that GCN2 is crucial for IDO-mediated immune suppression ( in vitro , and GCN2 knockout leads to decreased CD8+ T cell numbers, and reduced CD44 and granzyme B expression in CD8+ T cells within the tumor, resulting in reduced survival ( Role of methionine in T cell anti-tumor function Studies examining the role of methionine in regulating T cell anti-tumor function have yielded conflicting findings