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High glutamine-induced mTORC1 hyperactivation resulted in the suppression of mTORC2, which otherwise stabilizes RUNX2 via GSK3 inhibition through pAKT-473

For the second step of trypanothione synthesis glutathionylspermidine is bound in a way that preferentially allows N1-glutathionylation of N8-glutathionylspermidine, classifying N8-glutathionylspermidine as the favoured substrate

Despite the relative simplicity of FeS clusters in terms of structure and composition, their synthesis and assembly into apoproteins is a highly complex and coordinated process in living cells