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While it is known that skin cells can produce estrogens locally, aromatase enzyme activity is dramatically reduced to approximately 30 times lower than in premenopausal ovarian follicular tissue [10]

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Alternatively, they may act indirectly by up-regulating phase II antioxidant enzymes

Dall et al

Specifically, leveraging advanced imaging technologies alongside multi-omics sequencing of particular circulating biomarkers in the blood allows for the identification of biomarkers signaling copper metabolic disruption