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However, further experimental studies are required to substantiate the mechanism by which topiramate modulates these pathways and to confirm its efficacy in treating migraines

[12] Decline of Homosynaptic Plasticity in Older Adults [edit] The capacity for homosynaptic plasticity (like the ease of inducing LTP or LTD) tends to decline in older adults

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A healthcare provider can help assess potential interactions[10]
