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recently showed that folic acid treatment can inhibit atherosclerosis progression through the reduction of VSMC dedifferentiation in high-fat-fed LDL receptor-deficient mice [64]

The treated cells showed markedly reduced lipogenesis

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People Taking Certain Medications: Medications like metformin and proton pump inhibitors can interfere with B12 absorption

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

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