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Autophagy is involved in the metabolism coupling between TME and AML Recent studies have demonstrated that cancer cells can remodel the microenvironment into a self-reinforcing tumor microenvironment (TME) to support their survival and proliferation [127, 128]

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The most extensively documented involves upregulation of vascular endothelial growth factor (VEGF) and its receptor VEGFR2, promoting angiogenesis, the formation of new blood vessels, in injured tissue

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