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We extensively analyzed the transcriptome data available through the Gene Expression Omnibus (GEO) database, and found that pyroptosis-related genes were differentially expressed in OA synovial membrane tissues (Fig

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In the recent past, studies have gradually extended from physiological and biochemical analyses to conducting further investigation of molecular mechanisms and genetic properties (Nordstrm et al., 2021)

While DOI does not activate 5-HT 1A receptor, that has inhibitory effects on L5p neurons (Nichols, 2016), 5-MeO-DMT stands out among psychedelics due to its higher affinity for 5-HT 1A than for 5-HT 2A (Puigseslloses et al., 2024)

Transcription factor modulators such as elafibranor, a PPAR ligand, have advanced to phase III trials and demonstrated efficacy in improving lipid handling and reducing hepatic steatosis